Lomerizine is a voltage-dependent calcium channel blocker that inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons with IC50 values of 1.9 and 4 μM, respectively. It inhibits vasoconstriction induced by potassium chloride, serotonin (5-HT; Item No. 14332), or vasopressin in isolated rat basilar arteries when used at a concentration of 1 μM. Lomerizine (1 μM) reduces neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures. It reduces retinal damage in a rat model of retinal ischemia-reperfusion injury when administered...

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WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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Technical Documents

Datasheet (1)

YCDGz28374.pdf

MSDS (1)

LoGjD28374m.pdf

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Shipping & Handling

Shipped In

Wet ice in continental US; may vary elsewhere

Safety & Storage

Storage Temperature

-20°C

Safety Statement

WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Regulatory & Compliance

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