Acetamiprid

Acetamiprid is a neonicotinoid insecticide that acts as an agonist of insect nicotinic acetylcholine receptors (nAchRs). It activates nAchRs containing N. lugens α1 and rat β2 subunits with an EC50 value of 67 µM in X. laevis oocytes. Acetamiprid administered to pregnant mice at a dose of 1 mg/kg leads to sexual and aggressive behaviors in adult male offspring while doses of 1 and 10 mg/kg decrease anxiety-like behavior of adult male offspring in the light-dark transition test. Formulations containing acetamiprid have been used to control sucking insects on crops and pets.