MK-3102 is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.6 nM). It is selective for DPP-4 over several proteases, including DPP-7, DPP-8, DPP-9, and fibroblast activation protein (FAP; IC50s = >67 µM for all), as well as the ion channels delayed-rectifier potassium current (Ikr), L-type voltage-gated calcium channel 1.2 (Cav1.2), and voltage-gated sodium channel 1.5 (Nav1.5; IC50s = >30 µM for all) and a panel of 168 enzymes (IC50s = >10 µM for all). MK-3102 (0.3 mg/kg) reduces blood glucose levels by 51% in mice.

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WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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Technical Documents

Datasheet (1)

aNsJu21454.pdf

MSDS (1)

bmMPE21454m.pdf

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Shipping & Handling

Shipped In

Room Temperature in continental US; may vary elsewhere

Safety & Storage

Storage Temperature

-20°C

Safety Statement

WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Regulatory & Compliance

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