Sephin1 is a selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B. At 50 µM, it has been shown to prolong eIF2α phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced cytotoxicity. At 1-5 mg/kg, sephin1 has been shown to prevent defects resulting from protein misfolding in a mutant SOD1 mouse model of fast-progressing amyotrophic lateral sclerosis as well as a mouse model of Charcot-Marie-Tooth neuropathy.
Sephin1 is a selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B. At 50 µM, it has been shown to prolong eIF2α phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced cytotoxicity. At 1-5 mg/kg, sephin1 has been shown to prevent defects resulting from protein misfolding in a mutant SOD1 mouse model of fast-progressing amyotrophic lateral sclerosis as well as a mouse model of Charcot-Marie-Tooth neuropathy.
Shipping & Handling
Shipped In
Wet ice in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
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We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.