LH-846
Cayman Chemical
SKU / CAT#: 17686-1MG
$2800
usd$28.00/mg
LH-846
Cayman Chemical Company, Inc.SKU / CAT#: 17686-1MG
MPN: 17686
$2800
usd$28.00/mg
Available
SHIPS Sep 17th
Available
SHIPS Sep 17th
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Description
LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1δ (IC50 = 290 nM). It inhibits CK1ε and CK1α at much higher concentrations (IC50s = 1.3 and 2.5 μM, respectively) but does not inhibit CK2. LH 846 has been shown to inhibit CK1δ-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.
LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1δ (IC50 = 290 nM). It inhibits CK1ε and CK1α at much higher concentrations (IC50s = 1.3 and 2.5 μM, respectively) but does not inhibit CK2. LH 846 has been shown to inhibit CK1δ-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.
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Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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Datasheet (1)
MSDS (1)
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Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
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