Sodium butyrate is a short-chain fatty acid. It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk. Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay). It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM. Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells...
Sodium butyrate is a short-chain fatty acid. It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk. Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay). It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM. Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells...
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Room Temperature in continental US; may vary elsewhere
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Room temperature
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
Room temperature
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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