Piperlongumine is an alkaloid that has been found in P. longum and has anticancer and antioxidant activities. It binds to glutathione (GSH) and inhibits the protein-protein interaction between glutathione and glutathione S-transferase pi 1 (GSTP1), an enzyme that is often overexpressed in cancer cells. Piperlongumine reduces the viability of A549 and NCI H460 cells (IC50s = 14.91 and 13.72 µM, respectively). It also induces apoptosis and inhibits the DNA binding activity of NF-κB in A549 and NCI H460 cells. Piperlongumine (2.5 and 5 mg/kg twice per week) reduces tumor growth in an A549 mouse xenograft...
Piperlongumine is an alkaloid that has been found in P. longum and has anticancer and antioxidant activities. It binds to glutathione (GSH) and inhibits the protein-protein interaction between glutathione and glutathione S-transferase pi 1 (GSTP1), an enzyme that is often overexpressed in cancer cells. Piperlongumine reduces the viability of A549 and NCI H460 cells (IC50s = 14.91 and 13.72 µM, respectively). It also induces apoptosis and inhibits the DNA binding activity of NF-κB in A549 and NCI H460 cells. Piperlongumine (2.5 and 5 mg/kg twice per week) reduces tumor growth in an A549 mouse xenograft...
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WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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