Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619 (Item No. 16450) or PGD2 (Item No. 12010) in isolated guinea pig tracheal rings (pA2s = 8.7 and 8.6, respectively). It also reduces PGD2-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM. Ramatroban (5 mg/kg) inhibits ovalbumin-induced...
Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619 (Item No. 16450) or PGD2 (Item No. 12010) in isolated guinea pig tracheal rings (pA2s = 8.7 and 8.6, respectively). It also reduces PGD2-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM. Ramatroban (5 mg/kg) inhibits ovalbumin-induced...
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Room Temperature in continental US; may vary elsewhere
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Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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