Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY 41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. Surprisingly, NO donors synergize with BAY 41-8543 in stimulating recombinant sGC. BAY 41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo, BAY 41-8543 decreases blood pressure dose-dependently,...

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Shipped In

Room Temperature in continental US; may vary elsewhere

Hazardous

Safety & Storage

Storage Temperature

-20°C

Safety Statement

WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Regulatory & Compliance

Technical Documents

Datasheet (1)

mMTBx10011131.pdf

MSDS (1)

ewJvE10011131m.pdf

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