Anti-VEGFA Antibody

Primary

Polyclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

China

E, WB, IHC

VEGFA

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Rabbit

Human

Polyclonal

Unconjugated

ELISA: 1:2000-1:5000 Western blotting: 1:500-1:2000 Immunohistochemistry: 1:25-1:100

Synthetic peptide corresponding to a region derived from 130-143 amino acids of human vascular endothelial growth factor A

The antibody detects endogenous level of total VEGFA protein.

Supplied at 0.9mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

This gene is a member of the PDGF / VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.