Anti-Tyrosinase Antibody [T311] - BSA and Azide free

Primary

Monoclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

FC, IF, IHC-P

T311

Tyrosinase

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Liquid

1 mg/ml

Mouse

IgG2a

Human

Monoclonal

Unconjugated

Protein A/G chromatography.

FC: 0.5-1 µg / million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Recombinant Tyrosinase protein.

Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

kappa

Y