Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [M2-7C10 + M2-9E3 + T311 + HMB45]

Primary

Monoclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

WB, IHC-P

M2-7C10 + M2-9E3 + T311 + HMB45

Melanoma Marker (MART-1 + Tyrosinase + gp100)

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Liquid

200 µg/ml

Mouse

IgG2b, lambda + IgG2a, kappa + IgG1, kappa

Human

Monoclonal

Unconjugated

Protein A/G chromatography.

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Clone M2-7C10 & M2-9E3: Recombinant human MART-1 protein. Clone T311: Recombinant tyrosinase protein. Clone HMB45: Extract of pigmented melanoma metastases from lymph nodes.

This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.