Anti-N Cadherin Antibody [MNCD2]

Primary

Monoclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

FC, WB, IHC-P

MNCD2

N Cadherin

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Liquid

200 µg/ml

Rat

IgG2a

Human, Mouse, Chicken

Monoclonal

Unconjugated

Protein A/G chromatography.

FC: 1-2 µg / million cells, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Recombinant fragment, around amino acids 308-597, of mouse CDH2 protein. The epitope is the extracellular domain of N Cadherin.

Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.