Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/1029
*USAGE / SAFETY STATEMENT
This product is for in vitro research use only. Any other applications, such as diagnostics or therapeutics, or in vivo experiments, and the validation of this product therein, are solely at the responsibility of the buyer/user.
DISCLAIMER
This product is only warranted for the specifications as described in this product sheet and only when the product is handled and stored according to instructions. User should validate this antibody in the application and tissue/cell type as required, after confirmation of integrity upon receipt is obtained by reproducing the performance as described below. Should such confirmation not be attempted, any warranty is void. In case of non-conformance, user needs to contact us immediately for replacement or refund.
PURIFICATION
By Protein A from bioreactor concentrate
FORMULATION
0.2 mg IgG/ml in PBS with 0.05% BSA & 0.05% azide.
IMMUNOGEN
Recombinant full-length human TP16 protein
POSITIVE CONTROL
anaplastic thyroid carcinoma, pituitary gland, urothelial carcinoma
FORMULATION (WITHOUT BSA)
1mg igG/ml in PBS with 0.05% azide upon quotation
ALTERNATIVE NAME
Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Melanoma, cutaneous malignant 2; Multiple tumor suppressor 1; CDK4I; CDKN2; CDKN2A; CMM2; MTS1; MTS-1; p16; p16-INK4; p16-INK4A; p16INK4; p16INK4A; TP16
CELL. LOCALIZATION
cytoplasm, nucleus
IHC
AE00382 to TP16 was successfully used to stain nuclei in the pituitary gland anterior lobe, and cytoplasm and nuclei in thyroid carcinoma and urothelial carcinoma sections. Recommended concentration: 1-3 μg/ml
NORMAL TISSUE MICROARRAY VALIDATION (STRONG POSITIVE)
pituitary gland anterior lobe
NORMAL TISSUE MICROARRAY VALIDATION (WEAK TO MODERATE)
adrenal gland; appendix mucosa; breast; duodenum mucosa; endometrium, proliferation; endometrium, secretion; pancreas; prostate; sinus paranasalis; thymus ; tonsil; urothelium
NORMAL TISSUE MICROARRAY VALIDATION (NO STAIN)
adipose; appendix muscular wall; aorta media; bronchus mucosa; cerebellum; cerebrum; colon mucosa; colon muscular wall; duodenum Brunner gland; endocervix; ectocervix; epididymis; esophagus squamous epithelium; fallopian tube; gallbladder; heart muscle; ileum mucosa; liver; lung; lymph node; myometrium; ovarian stroma; parathyroid gland; parotid gland; placenta; rectum mucosa; renal cortex; renal medulla; seminal vesicle; skeletal muscle; skin ; spleen; stomach; testis; thyroid gland; urinary bladder muscular wall
CANCER TISSUE MICROARRAY VALIDATION (STRONG POSITIVE)
anaplastic thyroid carcinoma; cervix squamous cell carcinoma; high-grade serous carcinoma; leiomyosarcoma; liposarcoma; melanoma; Merkel cell carcinoma; oral squamous cell carcinoma; urinary bladder small cell carcinoma; urothelial carcinoma
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