Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/1280;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
Antigen affinity purification.
IMMUNOGEN
Full length fusion protein
SPECIFICITY
The antibody detects endogenous levels of total COL2A1 protein.
BACKGROUND
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
ALTERNAME
AOM; ANFH; SEDC; COL11A3
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Western blotting: 1:200-1:1000<br/>Immunohistochemistry: 1:15-1:50
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