Specifications
CLASS
Main-group Elements [Catalysis and Inorganic Chemistry]
SUBCLASS
Gallium [Catalysis and Inorganic Chemistry]
APPLICATION
Gallium-catalyzed Bromocyanation of Alkynes
Typical Procedure: A flame dried Schlenk flask is charged with GaCl3 (7.0 mg, 0.040 mmol) and ClCH2CH2Cl (1.6 mL), then BrCN (63.6 mg, 0.60 mmol) is added. After stirring at room temperature for 5 min, alkyne (0.40 mmol) is added, and the resulting mixture is stirred at 80 °C. After 12 hrs, the mixture is concentrated in vacuo. The residue is subjected to flash column chromatography on silica gel (hexane : AcOEt = 10 : 1 → 4 : 1) as eluents to afford the corresponding β-bromoacrylonitriles.
PUBCHEM SUBSTANCE ID
87561610.0
BEILSTEIN/REAXYS NUMBER
3587236.0
HAZARD STATEMENTS
H314 : Causes severe skin burns and eye damage.
H290 : May be corrosive to metals.
PRECAUTIONARY STATEMENTS
P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dusts or mists.
P234 : Keep only in original container.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P390 : Absorb spillage to prevent material damage.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P406 : Store in corrosive resistant container with a resistant inner liner.
P405 : Store locked up.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
White to Almost white powder to crystal
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