SCF (Stem Cell Factor, Stem Cell Factor Precursor, c-Kit Ligand, KIT Ligand, KitL, KITLG, KL-1, Mast Cell Growth Factor, MGF, Steel Factor, SF) (AP)

SCF is a type I transmembrane protein and hematopoietic growth factor, which acts in synergy with other growth factors and signals through the c-Kit receptor. Interaction between SCF and the receptor tyrosine kinase c-Kit is an essential step for the proliferation, survival and differentiation of hematopoietic progenitor cells, mast cells, myelanocytes and germ cells, and plays an important role in follicular development. Studies have shown involvement of the association between SCF and c-Kit with the progression and invasiveness of tumors, and deficiencies of either SCF or c-Kit result in mast...