PML protein is a tripartite motif (TRIM)-containing nuclear protein that may function as, among other things, a transcription factor, a coactivator of nuclear receptors, a regulator of apoptosis, a mediator of interferon-induced antiviral response, and as a suppressor of growth and oncogenic transformation. PML is localized to the nucleoplasm and in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). Localization of PML to Promyelocytic Leukemia Bodies requires modification of PML protein by the Small Ubiquitin Modifier (SUMO) and is required...
PML protein is a tripartite motif (TRIM)-containing nuclear protein that may function as, among other things, a transcription factor, a coactivator of nuclear receptors, a regulator of apoptosis, a mediator of interferon-induced antiviral response, and as a suppressor of growth and oncogenic transformation. PML is localized to the nucleoplasm and in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). Localization of PML to Promyelocytic Leukemia Bodies requires modification of PML protein by the Small Ubiquitin Modifier (SUMO) and is required...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Monoclonal Antibodies
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by Protein G affinity chromatography.
APPLICATION
IC WB
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide and a stabilizer. Labeled with Allophycocyanin (APC).
SUBCLASS
Transcription Factors
CLONE NUMBER
5H31 (36.1-104)
HOST SPECIES
mouse
ISOTYPE
IgG2b
IMMUNOGEN
6His fusion protein corresponding to aa1-581 of mouse PML (promyelocytic leukemia protein).
ANTIBODY TYPE
Mab
GRADE
Affinity Purified
CROSS REACTIVITY
Mo
SPECIFIC ACTIVITY
Recognizes mouse PML, Mr ~90-106kD, depending on degree of protein modification. Does not crossreact with human. MEF1 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with P4296. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.
COMMODITY CODE
30021010
HOST
mouse
SWISS PROT#
Q60953
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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