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IRS-1 (Insulin Receptor Substrate 1) (APC)
SKU / CAT#: I8700-02F-APC-100ul
$1,06200
usd
$1,062.00
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  4. IRS-1 (Insulin Receptor Substrate 1) (APC)
I8700-02F-APC-100ul

IRS-1 (Insulin Receptor Substrate 1) (APC)

United States Biological Corp
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SKU / CAT#: I8700-02F-APC-100ul
MPN: I8700-02F-APC-100ul
$1,06200
usd
$1,062.00
Available
SHIPS Jun 16th
Available
SHIPS Jun 16th
SKU
Unit size / Options
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Price
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Description
IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by...
IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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Specifications
CLASS
Monoclonal Antibodies
SUBCLASS
Protein Kinases
APPLICATION
IC IP WB
CLONE NUMBER
9H249 (4.2.2)
ACCESSION#
NP_005535.1
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by Protein G affinity chromatography.
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide and a stabilizer. Labeled with Allophycocyanin (APC).
GRADE
Affinity Purified
ANTIBODY TYPE
Mab
HOST SPECIES
mouse
ISOTYPE
IgG2a,k
CROSS REACTIVITY
Bo Ca Hu Mk Mo Po Rt
IMMUNOGEN
Synthetic peptide corresponding to aa431-446 of mouse IRS1. Epitope: Internal
SPECIFIC ACTIVITY
Recognizes mouse IRS1, MW ~185kD. Species Crossreactivity: human, rat. Predicted to cross-react with many other species based on 100% sequence homology with immunogen.
SWISS PROT#
P35569
COMMODITY CODE
30021010
HOST
mouse
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Badge
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