Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and...
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Monoclonal Antibodies
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by Protein G affinity chromatography.
APPLICATION
IC WB
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.6, 0.09% sodium azide, 30% glycerol. Labeled with Biotin. Biotin: Antibody Molar Ratio: 5:1
SUBCLASS
Histones
CLONE NUMBER
2T14 (JBW301)
HOST SPECIES
human
ISOTYPE
IgG1
IMMUNOGEN
KLH-conjugated, synthetic peptide (C-KATQA[pS]QEY) corresponding to aa134-142 of human histone H2A.X. Species sequence homology: A broad species crossreactivity is expected based on conservation of sequence homology. The immunizing sequence has 8 identical amino acids in yeast and mouse.
ACCESSION#
NM_002105.2
ANTIBODY TYPE
Mab
GRADE
Affinity Purified
CROSS REACTIVITY
Hu
SPECIFIC ACTIVITY
Recognizes human Histone H2A.X phosphorylated at Ser139, Mr 15kD.
COMMODITY CODE
30021010
HOST
mouse
SWISS PROT#
P16104
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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