Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that was discovered as a substrate for Src and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Phosphorylation of tyrosine 407 is activated by TGFb and Epithelial Mesenchyme Transition (EMT). Unlike other sites on FAK, tyrosine 407 is EGFR independent.
Applications:
Suitable for use in Western blot, Immunocytochemistry and
Immunohistochemistry. Other applications not tested.
Recommended...
Focal Adhesion Kinase (FAK) is a 125kD non-receptor protein tyrosine kinase that was discovered as a substrate for Src and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Phosphorylation of tyrosine 407 is activated by TGFb and Epithelial Mesenchyme Transition (EMT). Unlike other sites on FAK, tyrosine 407 is EGFR independent.
Applications:
Suitable for use in Western blot, Immunocytochemistry and
Immunohistochemistry. Other applications not tested.
Recommended...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C (-20°C Glycerol)
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
SUBCLASS
Tyrosine Kinases
APPLICATION
IC IHC WB
ACCESSION#
L13616
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by immunoaffinity chromatography.
PHYSICAL FORM
Supplied as a liquid in Dulbecco’s PBS (without Mg2+ and Ca2+), pH 7.3,1mg/ml BSA (IgG, protease free), 0.05% sodium azide, 50% glycerol.
GRADE
Affinity Purified
ANTIBODY TYPE
Pab
HOST SPECIES
human
ISOTYPE
IgG
CROSS REACTIVITY
Hu Mo Rt
IMMUNOGEN
Synthetic phosphopeptide derived from the region of human FAK that contains tyrosine 407.
SPECIFIC ACTIVITY
Recognizes human FAK when phosphoryated at Tyr407. Species Crossreactivity: mouse, rat, Species sequence homology: chicken, 100%; frog, 92%
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C (-20°C Glycerol)
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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