Oligodendrocyte-specific protein (OSP) is a putative four-transmembrane protein of 22kD. It is primarily expressed in oligodendrocytes of the CNS and Sertoli cells of testes in the adult mouse. OSP is the third most abundant CNS myelin protein and contributes to 7% of the total myelin protein. OSP shares sequence homology with the claudin family of tight junction (TJ) proteins. It forms TJs in cell culture and colocalizes with structures similar to TJs in myelin. Thus, it was renamed OSP/Claudin-11. OSP/Claudin-11-null mice lack intramembranous junctions in between Sertoli cells in testes and...
Oligodendrocyte-specific protein (OSP) is a putative four-transmembrane protein of 22kD. It is primarily expressed in oligodendrocytes of the CNS and Sertoli cells of testes in the adult mouse. OSP is the third most abundant CNS myelin protein and contributes to 7% of the total myelin protein. OSP shares sequence homology with the claudin family of tight junction (TJ) proteins. It forms TJs in cell culture and colocalizes with structures similar to TJs in myelin. Thus, it was renamed OSP/Claudin-11. OSP/Claudin-11-null mice lack intramembranous junctions in between Sertoli cells in testes and...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
SUBCLASS
Claudin
APPLICATION
E IF IP WB
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by immunoaffinity chromatography.
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Biotin.
GRADE
Affinity Purified
ANTIBODY TYPE
Pab
HOST SPECIES
human
ISOTYPE
IgG
CROSS REACTIVITY
Hu Mo
IMMUNOGEN
Synthetic peptide derived from the C-terminal region of human OSP/Claudin-11, which differs by only one amino acid from
mouse and rat sequences.
SPECIFIC ACTIVITY
Specific for human OSP/Claudin-11. Single band at ~22kD is observed when using C5838-62 at 0.5mg/ml or less in mouse brain homogenates. An additional band of ~44kD representing the dimerized protein may be observed at 1ug/ml.
Species Crossreactivity: mouse. Species Sequence Homology: rat
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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