The c-kit proto-oncogene is the cellular homologue of the feline sarcoma v-kit oncogene. It encodes a type III transmembrane receptor tyrosine kinase also known as CD117 or stem cell factor receptor (SCFR). c-Kit signaling is activated when a ligand known as steel factor or stem cell factor (SCF) binds to the receptor. Interactions between specific phosphotyrosine residues of activated receptor tyrosine kinases (RTKs) and Src homology 2 (SH2) domains define cellular
growth and differentiation signals. It has been reported that SCF stimulates the association of the p85 subunit of PI3K with the...
The c-kit proto-oncogene is the cellular homologue of the feline sarcoma v-kit oncogene. It encodes a type III transmembrane receptor tyrosine kinase also known as CD117 or stem cell factor receptor (SCFR). c-Kit signaling is activated when a ligand known as steel factor or stem cell factor (SCF) binds to the receptor. Interactions between specific phosphotyrosine residues of activated receptor tyrosine kinases (RTKs) and Src homology 2 (SH2) domains define cellular
growth and differentiation signals. It has been reported that SCF stimulates the association of the p85 subunit of PI3K with the...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
SUBCLASS
CD Markers
APPLICATION
IP WB
ACCESSION#
NP_000213.1, BC071593
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by epitope affinity chromatography.
PHYSICAL FORM
Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with R-Phycoerythrin (PE).
GRADE
Purified
ANTIBODY TYPE
Pab
HOST SPECIES
human
ISOTYPE
IgG
CROSS REACTIVITY
Hu
IMMUNOGEN
Synthetic peptide derived from an internal sequence of the human c-Kit protein
SPECIFIC ACTIVITY
Reacts with the human c-Kit (CD117 or stem cell factor receptor (SCFR)) oncoprotein. On Western blots, this antibody identifies a ~145kD band representing the mature (phosphorylated, glycosylated) form of c-Kit, a ~125kD band for the immature form, and a ~95kD band representing the soluble form. Reactivity has been confirmed with human GIST-882 and EWS-502 cell lysates.
COMMODITY CODE
30021010
HOST
rabbit
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
4°C Do Not Freeze
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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