ACAT1 (Acetyl-CoA Acetyltransferase, Mitochondrial, Acetyl-CoA Acetyltransferase 1)

ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. The gene encoding ACAT1 spans approximately 27 kb and contains 12 exons interrupted by 11 introns. Defects in this gene are associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. Applications: Suitable for use in Immunohistochemistry, Western Blot. Other applications not tested. Recommended...