VDAC1 (mVDAC5, OMP2, outer Mitochondrial Membrane Protein porin 1, plasmalemmal porin, porin 31HL, porin 31HM, PORIN, VDAC 5, Voltage-Dependent Anion-selective Channel Protein 1)

Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. Applications:...