MDM2, phosphorylated (S166) (E3 Ubiquitin-Protein Ligase Mdm2, Double minute 2 Protein, Hdm2, OncoProtein Mdm2, p53-Binding Protein Mdm2, MDM2)

p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a...