MAD1L1 (Mitotic spindle assembly Checkpoint Protein MAD1, Mitotic arrest deficient 1-like Protein 1, MAD1-like Protein 1, Mitotic Checkpoint MAD1 Protein Homolog, HsMAD1, hMAD1, Tax-Binding Protein 181, MAD1L1, MAD1, TXBP181)

MAD1 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated...