IFN-R1 (Interferon alpha/beta Receptor 1, IFN-R-1, IFN-alpha/beta Receptor 1, Cytokine Receptor class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I interferon Receptor 1, IFNAR1, IFNAR, IFNR1, IFN R1, IFN-alpha/betaRalpha,IFN-alpha/betaR1, IFN alpha/betaRalpha, IFNalpha/betaR1, IFNalpha/beta-Ralpha, IFNalpha/beta R1,)

The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-y) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha...