HSP90alpha (Heat Shock Protein HSP 90-alpha, Heat Shock 86kD, HSP 86, HSP86, Lipopolysaccharide-Associated Protein 2, LAP-2, LPS-Associated Protein 2, Renal Carcinoma Antigen NY-REN-38, HSP90AA1, HSP90A, HSPC1, HSPCA)

In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell...