HMGCR (3 hydroxy 3 methylglutaryl Coenzyme A Reductase, 3 hydroxymethylglutaryl CoA Reductase, 3-hydroxy-3-methylglutaryl-coenzyme A Reductase, 3H3M, HMDH, HMG CoA Reductase, HMG CoAR, HMG-CoA Reductase, Hmgcr, Hydroxymethylglutaryl CoA Reductase, LDLCQ3, MGC103269, Red)

The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate...