HLA-DQB2 (HLA class II histocompatibility Antigen, DQ beta 2 Chain, HLA class II histocompatibility Antigen, DX beta Chain, MHC class II Antigen DQB2, HLA-DQB2, HLA-DXB)

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T-cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ,...