FANCG (NA Repair Protein XRCC9, DNA-Repair Protein XRCC9, FAG, FANCG, FANCG_HUMAN, Fanconi anaemia complementation group G, Fanconi anemia group G Protein, Protein FACG, X ray Repair, Complementing defective, in Chinese hamster Cells 9, X-Ray Repair, Complementing defective, in Chinese hamster, 9, XRCC9,)

Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F, and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF-alpha...