Endo180 (C-Type Mannose Receptor 2, C-Type Lectin Domain Family 13 Member E, Endocytic Receptor 180, Macrophage Mannose Receptor 2, Urokinase-Type plasminogen Activator Receptor-Associated Protein, UPAR-Associated Protein, Urokinase Receptor-Associated Protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP)

Endo180 (Endocytic receptor 180), also known as macrophage mannose receptor C type 2 (MRC2), urokinase plasminogen activator receptor-associated protein (uPARAP) or CD280 antigen, is a ubiquitously expressed, type I membrane protein with predominant expression in fetal lung and kidney. The extracellular domain of Endo180 contains a fibronectin type II domain, eight C-type lectin domains and a cysteine-rich domain. Endo180 functions as a cell surface receptor and mediates collagen matrix remodeling as well as cell migration by playing a role in the uptake and lysosomal degradation of collagen....