Elk1, phosphorylated (S383) (ELK 1, Elk1, ELK1 Member of ETS OncoGene Family, ELK1 Protein, ELK1, ELK2 Member of ETS OncoGene Family, ETS Domain Containing Protein Elk 1, ETS Domain Containing Protein Elk1, ETS Domain Protein Elk1, ETS Domain-Containing Protein Elk-1, ETS like Gene 1, Member of ETS OncoGene Family, OncoGene Elk1, Tyrosine Kinase (ELK1) OncoGene)

Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element. Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by...