eIF6 (Eukaryotic Translation Initiation Factor 6, eIF-6, B(2)GCN Homolog, B4 integrin Interactor, CAB, p27(BBP), EIF6, EIF3A, ITGB4BP, OK/SW-cl.27)

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications...