eIF4E, phosphorylated (S209) (eIF4E ( phospho S209), eIF-4E, eIF4E, mRNA cap-Binding Protein, eIF-4F 25kD Subunit, EIF4E, 1977, EIF4E, 133440, P06730, CBP, EIF4EL1, EIF4F, MGC111573)

eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated...