eIF2alpha, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2alpha controls the rate of tRNA translation. When eIF2alpha is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2alpha is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
Applications:
Suitable for use in Western Blot, Immunohistochemistry....
eIF2alpha, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2alpha controls the rate of tRNA translation. When eIF2alpha is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2alpha is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
Applications:
Suitable for use in Western Blot, Immunohistochemistry....
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
CLASS
Polyclonal Antibodies
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURITY
Purified by immunoaffinity chromatography.
APPLICATION
IHC WB
PHYSICAL FORM
Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
SUBCLASS
Translation Initiation Factors
HOST SPECIES
human
ISOTYPE
IgG
IMMUNOGEN
Synthetic phosphopeptide derived from human eIF2α around the phosphorylation site of Serine 51.
ANTIBODY TYPE
Pab
GRADE
Affinity Purified
CROSS REACTIVITY
Hu Mo Rt
SPECIFIC ACTIVITY
Recognizes endogenous levels of eIF2alpha, phosphorylated S51. Species Crossreactivity: Human, mouse, rat
COMMODITY CODE
30021010
HOST
rabbit
SWISS PROT#
P05198
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Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
-20°C
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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