EGFR, phosphorylated (Y1086) (Epidermal Growth Factor Receptor, EC=2.7.10.1, Proto-Oncogene c-ErbB-1, Receptor Tyrosine-Protein Kinase erbB-1, ERBB, ERBB1, HER1, EGFR)

Epidermal growth factor mediates its effects on cell growth through its interaction with a cell surface glycoprotein designated the EGF receptor. Binding of EGF or TGFalpha to the EGF receptor activates tyrosine-specific protein kinase activity intrinsic to the EGF receptor. The carboxy-terminal tyrosine residues on EGFR, Tyr 1068 and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. Once activated, EGFR mediates the binding of the phosphotyrosine binding (PTB) domain of GRB2 through direct interactions with Tyr 1068 and Tyr 1086 and through indirect...