PCNA (Proliferating Cell Nuclear Antigen, DNA Polymerase Delta Auxiliary Protein, OTTHUMP00000030189, OTTHUMP00000030190, MGC8367) (HRP)

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended...