SLC4A1 (AE1, DI, EPB3, Band 3 Anion Transport Protein, Anion Exchange Protein 1, Solute Carrier Family 4 Member 1, CD233, MGC116750, MGC116753, MGC126619, MGC126623) (PE)

The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kD domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive...