MAP2K1 (Mitogen-activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAPK/ERK Kinase 1, MEK1, MAPKK 1, MAPKK1, MEK 1, MKK1, Dual Specificity Mitogen-activated Protein Kinase Kinase 1, ERK Activator Kinase 1, PRKMK1) (APC)

MEK1 is an integral component of the MAP kinase cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in brain. Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Conversely there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase are Thr292 and Thr386. human MEK1 gene is localized on chromosomal region 15q22.1-q22.33. Applications: Suitable for use in ELISA and Western Blot. Other applications...