KIAA1967 (DBIRD Complex Subunit KIAA1967, Deleted in Breast Cancer Gene 1 Protein, DBC-1, DBC.1, p30 DBC, DBC1) (FITC)

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Applications: Suitable for use in Immunofluorescence, FLISA and...