Specifications
RESEARCH AREA
Cell Signaling | Protein Phosphorylation | Serine / Threonine Kinases | MAPK Pathway | Cancer
ALTERNATIVE NAMES
ERK4 Antibody, ERK3 Antibody, ERK3 related Antibody, MAPK4 Antibody, Extracellular signal regulated kinase 4 Antibody, MAP kinase 4 Antibody, MAP kinase isoform p63 Antibody, MAPK4 Antibody, Mitogen activated protein kinase 4 Antibody, MK04_HUMAN Antibody, p63MAPK Antibody, PRKM4 Antibody
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
GENE ID
https://www.ncbi.nlm.nih.gov/gene/5596
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
ANTIBODY TYPE
WB (1:250); optimal dilutions for assays should be determined by the user.
PURIFICATION
Peptide Affinity Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
GENE ALIAS
MAPK4 (pSer186)
IMMUNOGEN
A phospho-specific peptide corresponding to residues surrounding Ser186 of human MAPK4 (AA183-190)
SPECIFICITY
Detects 62.623 kDa.
STORAGE BUFFER
PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2707971
CELLUAR LOCALIZATIONS
Cytoplasm | Nucleus
TISSUE SPECIFICITY
Highly expressed in heart and brain.
SCIENTIFIC BACKGROUND
MAPK4 is a protein-serine/threonine kinase that phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. MAPK4 may promote entry in the cell cycle.
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