Specifications
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
ANTIBODY TYPE
WB (1:1000); optimal dilutions for assays should be determined by the user.
REACTIVITY SPECIES
Human | Mouse | Rat
PURIFICATION
Protein G Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
IMMUNOGEN
KDEL peptide (C-AVKDEL -COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA)
SPECIFICITY
Detects KDEL tagged proteins.
STORAGE BUFFER
PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2729135
SCIENTIFIC BACKGROUND
The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.
REFERENCES
1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610.
2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438.
RESEARCH AREA
Cell Signaling | Tags and Cell Markers | Organelle Markers | Protein Trafficking | Chaperone Proteins
ALTERNATIVE NAMES
KDEL Antibody, Lys Asp Glu Leu Antibody, Lys-Asp-Glu-Leu (KDEL) Antibody, Lys-Asp-Glu-Leu Antibody, Lysine-aspartic acid-glutamate-leucine Antibody
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