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HSP90 Antibody, Clone 4F3.E8: FITC
StressMarq Biosciences Inc.
SKU / CAT#: SMC-149B-FITC
$42700
usd
$2.13/µg
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SMC-149B-FITC

HSP90 Antibody, Clone 4F3.E8: FITC

StressMarq Biosciences Inc.
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SKU / CAT#: SMC-149B-FITC
MPN: SMC-149B-FITC
$42700
usd
$2.13/µg
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Available
SHIPS Jul 3rd
Available
SHIPS Jul 3rd
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Description
Mouse Anti-Human HSP90 (total) Monoclonal IgG2a
Mouse Anti-Human HSP90 (total) Monoclonal IgG2a
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Conjugated antibodies should be stored at 4ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
HSP90 Antibody, Clone 4F3.E8: FITC
MSDS (1)
HSP90 Antibody, Clone 4F3.E8: FITC
Specifications
CLASS
Monoclonal
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
COUNTRY OF ORIGIN
Canada
APPLICATION
WB, IHC, ICC/IF, IP, ELISA
GENE ID
https://www.ncbi.nlm.nih.gov/gene/3320
UNIPROT ID
P07900
CLONE NUMBER
4F3.E8
ACCESSION#
NP_001017963.2
UNSPSC CODE
12352203.0
RIDADR
Non-hazardous
UN NUMBER
Non-hazardous
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
CONCENTRATION
1 mg/ml
ANTIBODY TYPE
WB (1:2000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
HOST SPECIES
Mouse
ISOTYPE
IgG2a
REACTIVITY SPECIES
Human | Mouse | Rat | Plant | Wheat (Triticum spp.)
CONJUGATION/TAG
FITC
PURIFICATION
Protein G Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
GENE ALIAS
HSP90
IMMUNOGEN
Recombinant Human HSP90 purified from E.coli
SPECIFICITY
Detects ~90kDa. This antibody detects both ? and ? forms of HSP90 equally well.
STORAGE BUFFER
PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2698392
CELLUAR LOCALIZATIONS
Cytoplasm | Melanosome
SCIENTIFIC BACKGROUND
HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms α and β, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90α exists predominantly as a homodimer while HSP90β exists mainly as a monomer (2). From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (3-6). Furthermore, HSP90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (7-8). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase (5). When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (9). For more information visit our HSP90 Scientific Resource Guide at http://www.HSP90.ca.
REFERENCES
1. Nemoto T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18: 306–360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420–434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324–8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889.
RESEARCH AREA
Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers
ALTERNATIVE NAMES
HSP84 Antibody, HSP86 Antibody, HSP90A Antibody, HSP90AA1 Antibody, HSP90AB1 Antibody, HSP90B Antibody, HSPC1 Antibody, HSPC2 Antibody, HSPCAL1 Antibody, HSPCAL4 Antibody
SWISS-PROT
P07900
Questions & Answers (0)
Citations (0)
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Conjugated antibodies should be stored at 4ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
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