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HSP70/HSC70 Antibody, Clone BB70: ATTO 594
StressMarq Biosciences Inc.
SKU / CAT#: SMC-106B-A594
$44400
usd
$2.22/µg
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  4. HSP70/HSC70 Antibody, Clone BB70: ATTO 594
SMC-106B-A594

HSP70/HSC70 Antibody, Clone BB70: ATTO 594

StressMarq Biosciences Inc.
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SKU / CAT#: SMC-106B-A594
MPN: SMC-106B-A594
$44400
usd
$2.22/µg
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Available
SHIPS Jul 7th
Available
SHIPS Jul 7th
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Description
Mouse Anti-Chicken HSP70/HSC70 Monoclonal IgG2a
Mouse Anti-Chicken HSP70/HSC70 Monoclonal IgG2a
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Conjugated antibodies should be stored at 4ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
HSP70/HSC70 Antibody, Clone BB70: ATTO 594
MSDS (1)
HSP70/HSC70 Antibody, Clone BB70: ATTO 594
Specifications
CLASS
Monoclonal
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
COUNTRY OF ORIGIN
Canada
APPLICATION
WB, ICC/IF, IHC, IP
GENE ID
https://www.ncbi.nlm.nih.gov/gene/423504
UNIPROT ID
P08106
CLONE NUMBER
BB70
ACCESSION#
NP_001006686.1
UNSPSC CODE
12352203.0
RIDADR
Non-hazardous
UN NUMBER
Non-hazardous
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
CONCENTRATION
1 mg/ml
ANTIBODY TYPE
WB (1:1000), IHC (1:200), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.
HOST SPECIES
Mouse
ISOTYPE
IgG2a
REACTIVITY SPECIES
Human | Mouse | Rat | Bovine | Sheep | Dog | Beluga | Fish | Guinea Pig (Cavia porcellus) | Pig | Hamster | Rabbit | Chicken | African clawed frog (Xenopus laevis) | Fruit Fly (Drosophila melanogaster) | Yeast
CONJUGATION/TAG
ATTO 594
PURIFICATION
Protein G Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
GENE ALIAS
HSP70/HSC70
IMMUNOGEN
Chicken HSP70/HSP90 complex
SPECIFICITY
Detects ~72 (HSP) and ~73kDa (HSC).
STORAGE BUFFER
PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2697856
CELLUAR LOCALIZATIONS
Cytoplasm
SCIENTIFIC BACKGROUND
HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 50% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5). All HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. For more information visit our HSP70 Scientific Resource Guide at http://www.HSP70.com.
REFERENCES
1. Zho J. (1998) Cell 94 : 471-480. 2. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J. Mol. Evol.38 (1): 1-17. 3. Rothman J. (1989) Cell 59: 591 -601. 4. DeLuca-Flaherty et al. (1990) Cell 62: 875-887. 5. Bork P., Sander C. & Valencia A. (1992) Proc. Nat Acad. Sci. USA 89: 7290-7294. 6. Fink A.L. (1999) Physiol. Rev. 79: 425-449. 7. Smith D.F., et al, (1993) Mol. Cell. Biol. 13(2): 869-876. 8. Prapapanich V., et al. (1996) Mol. Cell. Biol. 16(11):6200-6207. 9. Fernandez-Funez et al., (2000) Nature 408(6808): 101-106.
RESEARCH AREA
Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers | Cancer | Heat Shock
ALTERNATIVE NAMES
HSC54 Antibody, HSC70 Antibody, HSC71 Antibody, HSP70 1 Antibody, HSP701/HSP70 2 Antibody, HSP70.1 Antibody, HSP71 Antibody, HSP72 Antibody, HSP73 Antibody, HSPA1 Antibody, HSPA10 Antibody, HSPA1A Antibody, HSPA1B Antibody, LAP1 Antibody, NIP71 Antibody
SWISS-PROT
P08106
EXPRESSION SYSTEM
E. coli
Questions & Answers (0)
Citations (0)
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Conjugated antibodies should be stored at 4ºC
Safety Statement
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Regulatory & Compliance
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