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TIM-3 Antibody / HAVCR2
SKU / CAT#: V9177SAF-100UG
$49900
usd
$4.99/UG
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  4. TIM-3 Antibody / HAVCR2
V9177SAF-100UG

TIM-3 Antibody / HAVCR2

NSJ Bioreagents
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SKU / CAT#: V9177SAF-100UG
MPN: V9177SAF-100UG
$49900
usd
$4.99/UG
Available
SHIPS Jul 7th
Available
SHIPS Jul 7th
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Description
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cell tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and...
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cell tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the TIM-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This TIM-3 antibody is available for research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
DoSDvtim-3-antibody-tim3-4027-v9177
Specifications
CLASS
Primary Antibodies
SUBCLASS
Monoclonal
UNIPROT ID
Q8TDQ0
CLONE NUMBER
TIM3/4027
*USAGE / SAFETY STATEMENT
This TIM-3 antibody is available for research use only.
FORMAT
Purified (Sodium Azide Free)
APPLICATION.1
WB, IHC-P
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG2b, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein A/G affinity
IMMUNOGEN
A portion of amino acids 22-202 was used as the immunogen for the TIM-3 antibody.
STORAGE BUFFER
1 mg/ml in 1X PBS; BSA free, sodium azide free
APPLICATION DETAILS
Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
APPLICATION NOTES
Optimal dilution of the TIM-3 antibody should be determined by the researcher.
LOCALIZATION
Cell Surface
Questions & Answers (0)
Citations (0)
Western blot testing of human spleen tissue lysate using TIM-3 antibody (clone TIM3/4027). Expected molecular weight: 33-70 kDa depending on glycosylation level.
Western blot testing of human spleen tissue lysate using TIM-3 antibody (clone TIM3/4027). Expected molecular weight: 33-70 kDa depending on glycosylation level.
SDS-PAGE analysis of purified, BSA-free TIM-3 antibody (clone TIM3/4027) as confirmation of integrity and purity.
+1
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using TIM-3 antibody (clone TIM3/4027). These results demonstrate the foremost specificity of the TIM3/4027 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the TIM-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This TIM-3 antibody is available for research use only.
Regulatory & Compliance
Badge
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