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Ribonucleotide Reductase M1 Antibody / RRM1
SKU / CAT#: V8809-100UG
$49900
usd
$4.99/UG
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V8809-100UG

Ribonucleotide Reductase M1 Antibody / RRM1

NSJ Bioreagents
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SKU / CAT#: V8809-100UG
MPN: V8809-100UG
$49900
usd
$4.99/UG
Available
SHIPS Jul 7th
Available
SHIPS Jul 7th
SKU
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Description
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the RRM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This RRM1 antibody is available for research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
edjJPrrm1-antibody-ribonucleotide-reductase-m1-rrm1-4372r-v8809
Specifications
CLONE NUMBER
RRM1/4372R
CLASS
Primary Antibodies
SUBCLASS
Recombinant Monoclonal
UNIPROT ID
IDP23921
*USAGE / SAFETY STATEMENT
This RRM1 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
IHC-P
HOST SPECIES
Rabbit
ISOTYPE
Rabbit IgG
REACTIVITY SPECIES
Human
CLONALITY
Recombinant Rabbit Monoclonal
PURIFICATION
Protein A/G affinity
IMMUNOGEN
A portion of amino acids 700-800 of human RRM1 was used as the immunogen for the RRM1 antibody.
STORAGE BUFFER
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
APPLICATION DETAILS
Immunohistochemistry (FFPE): 1-2ug/ml
APPLICATION NOTES
Optimal dilution of the RRM1 antibody should be determined by the researcher.
LOCALIZATION
Cytoplasm
Questions & Answers (0)
Citations (0)
SDS-PAGE analysis of purified, BSA-free RRM1 antibody (RRM1/4372R) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free RRM1 antibody (RRM1/4372R) as confirmation of integrity and purity.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using RRM1 antibody (clone RRM1/4372R). These results demonstrate the foremost specificity of the RRM1/4372R mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
+1
IHC staining of FFPE human small intestine tissue with RRM1 (clone RRM1/4372R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the RRM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This RRM1 antibody is available for research use only.
Regulatory & Compliance
Badge
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