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Cyclin D1 Antibody / CCND1
SKU / CAT#: V8652-100UG
$49900
usd
$4.99/UG
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V8652-100UG

Cyclin D1 Antibody / CCND1

NSJ Bioreagents
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SKU / CAT#: V8652-100UG
MPN: V8652-100UG
$49900
usd
$4.99/UG
Available
SHIPS Jul 3rd
Available
SHIPS Jul 3rd
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Description
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant Cyclin D1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant Cyclin D1 antibody is available for research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
qkyaHrecombinant-cyclin-d1-antibody-rccnd1-4752-v8652
Specifications
CLASS
Primary Antibodies
SUBCLASS
Recombinant Monoclonal
UNIPROT ID
P24385
CLONE NUMBER
rCCND1/4752
*USAGE / SAFETY STATEMENT
This recombinant Cyclin D1 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
IHC-P
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG2a, kappa
REACTIVITY SPECIES
Human
CLONALITY
Recombinant Mouse Monoclonal
PURIFICATION
Protein G affinity chromatography
IMMUNOGEN
A portion of amino acids 200-295 from the human protein was used as the immunogen for the recombinant Cyclin D1 antibody.
STORAGE BUFFER
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
APPLICATION DETAILS
Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
APPLICATION NOTES
Optimal dilution of the recombinant Cyclin D1 antibody should be determined by the researcher.
LOCALIZATION
Nuclear
Questions & Answers (0)
Citations (0)
IHC staining of FFPE human mantle cell carcinoma with recombinant Cyclin D1 antibody (clone rCCND1/4752). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human mantle cell carcinoma with recombinant Cyclin D1 antibody (clone rCCND1/4752). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant Cyclin D1 antibody (clone rCCND1/4752) as confirmation of integrity and purity.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant Cyclin D1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant Cyclin D1 antibody is available for research use only.
Regulatory & Compliance
Badge
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