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SDHB Antibody
SKU / CAT#: V8073-100UG
$49900
usd
$4.99/UG
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V8073-100UG

SDHB Antibody

NSJ Bioreagents
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SKU / CAT#: V8073-100UG
MPN: V8073-100UG
$49900
usd
$4.99/UG
Available
SHIPS Jul 4th
Available
SHIPS Jul 4th
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Description
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the SDHB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This SDHB antibody is available for research use only.
Regulatory & Compliance
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Technical Documents
Datasheet (1)
EYxYjsdhb-antibody-sdhb-2382-v8073
Specifications
CLASS
Primary Antibodies
SUBCLASS
Monoclonal
UNIPROT ID
P21912
CLONE NUMBER
SDHB/2382
*USAGE / SAFETY STATEMENT
This SDHB antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
WB
HOST SPECIES
Mouse
ISOTYPE
Mouse IgG2b, kappa
REACTIVITY SPECIES
Human
CLONALITY
Monoclonal (mouse origin)
PURIFICATION
Protein G affinity chromatography
IMMUNOGEN
A recombinant human partial protein (amino acids 165-273) were used as the immunogen for this SDHB antibody.
STORAGE BUFFER
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
APPLICATION DETAILS
Western blot: 0.5-1ug/ml
APPLICATION NOTES
Optimal dilution of the antibody should be determined by the researcher.
Questions & Answers (0)
Citations (0)
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using SDHB antibody (clone SDHB/2382). These results demonstrate the foremost specificity of the SDHB/2382 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using SDHB antibody (clone SDHB/2382). These results demonstrate the foremost specificity of the SDHB/2382 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free SDHB antibody (clone SDHB/2382) as confirmation of integrity and purity.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the SDHB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This SDHB antibody is available for research use only.
Regulatory & Compliance
Badge
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